Although the unadjusted correlation value results from a prospective, multicenter, randomized, open-label, parallel-group study covariate adjustment drove wha correlation analysis considerably further from statistical. Design Prespecified subgroup analysis of. Patients received hydrochlorothiazide.
March 16, at pm. This disparity may be attributed to different study methods. However, given the lack of any significant difference in glucose level elevations among patients who maintained a serum potassium level of 4. Arch Intern Med. Thiazide diuretics, potassium, and the development of diabetes: a quantitative review. All participants provided written informed consent, and the institutional review boards of participating study centers approved the study protocol. Although the scarcity of comparative data makes such comparisons difficult, it is unknown whether there are clinically significant differences in serum potassium depletion potential between agents. Discussion After 9 weeks of hydrochlorothiazide monotherapy, there were significant increases in fasting serum glucose levels and significant reductions in serum potassium concentrations. Hall, M.
To determine whether changes in serum glucose, serum potassium, and plasma insulin levels are correlated in a cohort of hypertensive patients. Prespecified subgroup analysis of results from a prospective, multicenter, randomized, open-label, parallel-group study. Community-based ambulatory population of patients age range 17—65 yrs with a new diagnosis of hypertension, untreated hypertension, or known hypertension, who were previously treated with fewer than three antihypertensive drugs and had no evidence of cardiovascular disease or diabetes mellitus. Monotherapy with oral hydrochlorothiazide Fasting serum glucose, serum potassium, and plasma insulin levels were obtained at baseline before hydrochlorothiazide therapy was started and after 9 weeks of therapy. Changes in serum glucose levels did not differ significantly between patients maintaining serum potassium levels of 4.