Tag Archives: Menopausal

Pilot Study of Neurosteroid Ganaxolone for Menopausal Depression

Over the last few years we have heard a great deal about neurosteroids, also known as neuroactive steroids.  This class of compounds are steroid hormones produced in the brain and endocrine tissues which can modulate neurotransmission.  Animal studies have demonstrated that neurosteroids have a broad range of activities, including antidepressant, anxiolytic, sedative, analgesic, anticonvulsant, neuroprotective,… Read More »

New Research Study: Pregnenolone Neurosteroid for the Treatment of Menopausal Depression

Over the last few years we have heard a great deal about neurosteroids, also known as neuroactive steroids.  This class of compounds are steroid hormones produced in the brain and endocrine tissues which can modulate neurotransmission.  Animal studies have demonstrated that neurosteroids have a broad range of activities, including antidepressant, anxiolytic, sedative, analgesic, anticonvulsant, neuroprotective,… Read More »

Menopausal Depression is Common, Who Is at Risk?

Patients and clinicians may not be fully aware that women are at increased risk for depression during the menopausal transition.  The U.S. Preventive Services Task Force (USPSTF) recommends that clinicians screen all adults for depression, highlighting the importance of screening in populations at particularly high risk for depression.  While these recommendations have prompted increased awareness… Read More »

Neurokinin Receptor Antagonists for the Treatment of Menopausal Symptoms

About 80% of women experience vasomotor symptoms (VMS) – hot flashes and night sweats — as they transition into the menopause phase.  For most, the symptoms are manageable, but for a sizeable subset of midlife women, these symptoms can negatively affect sleep, mood, and quality of life.  While clinical guidelines suggest that menopausal vasomotor symptoms… Read More »